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We’re not saying hypochlorous acid sprays can do everything…but these multitasking skin-care products do tackle an impressive array of issues. The active ingredient, hypochlorous acid, forms when chlorine reacts with water and has potent antimicrobial properties—making it an effective salve for skin conditions ranging from rosacea to sunburns and more. Rachel Day, MD, a board-certified dermatologist based in Coral Gables, Florida, explains it like this: “Hypochlorous acid is a naturally occurring molecule your immune system produces to help fight off infection and support healing. In dermatology, we use hypochlorous acid spray as a gentle topical formulation to reduce inflammation, calm irritated skin, and keep bacteria in check—without disrupting the skin barrier.”
Our Top Hypochlorous Acid Sprays
- Best Overall: Prequel Hypochlorous Acid Spray, $17
- Best for Sensitive Skin: Tower 28 SOS Daily Rescue Facial Spray, $28
- Best for Stressed Skin: Personal Day Trust Me On This Hypochlorous Acid Spray, $27
- Best Prescription-Strength: SkinSmart Antimicrobial Eczema Therapy, $17
- Best Post-Procedure: Magic Molecule Daily Antimicrobial Skin Spray, $20
- Best for Families: Briotech Topical Skin Spray, $17
Furthermore, Dr. Day says that the bacteria-fighting ingredient is particularly helpful for conditions like eczema or acne; it’s also a boon for skin irritation. “I often recommend hypochlorous-based products to my patients with eczema as part of a personalized, barrier-friendly skin-care plan,” she says. “It’s also great for younger patients who sweat a lot and play sports.” Sold yet? Because we have been. If you want in, too, we’ve rounded up the best fine mists with heavy-hitting benefits and little to no side effects.
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Best Overall: Prequel Hypochlorous Acid Spray
Prequel
Hypochlorous Acid Spray
$17
Amazon
Jesa Marie Calaor applying Prequel Hypochlorous Acid Spray
Jesa Marie Calaor
Why we love it: Beloved at Allure HQ, in dermatologists’ offices, and beyond, Prequel’s Hypochlorous Acid Spray is like the little black dress of its category. Simple, versatile, and refined, it earns high praise from the pros. “This formula is super soothing, hydrating, and refreshing,” says Anna Chacon, MD, a board-certified dermatologist based in Miami. “It cleanses and purifies the skin, and it’s great for skin-barrier health. It also addresses skin-texture issues, dryness, and redness.” In addition to hypochlorous acid and electrolyzed water—which helps the formula cleanse the skin—Prequel’s spray is steeped in a mineral solution that helps dry skin retain hydration. Therefore, don’t be surprised if your complexion starts looking glowier and plumper after a few spritzes of this become a regular part of your routine.
Jesa Marie Calaor before applying Prequel Hypochlorous Acid Spray
Jesa Marie Calaor
Jesa Marie Calaor after applying Prequel Hypochlorous Acid Spray
Jesa Marie Calaor
Tester feedback from senior editor Jesa Marie Calaor
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“Wake up (redness). Work out (redness). Touch my face (more redness). My skin is extremely prone to inflammation, welting, and sensitivity. A quick all-over spritz calms my skin in minutes. I love the spray nozzle on this product—it creates a fine, even mist. As you can see from my before and after photos, this spray significantly reduced the welt I had at the corner of my mouth.” —Jesa Marie Calaor, senior editor
More to know
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- All ingredients: hypochlorous acid, electrolyzed water, mineral concentrate
- Sizes: 4 fl oz.
Best for Sensitive Skin: Tower 28 SOS Daily Rescue Facial Spray
Tower 28
SOS Daily Rescue Facial Spray
$28
Revolve
$28
Sephora
Nicola Dall’Asen applying Tower 28 SOS Daily Rescue Facial Spray
Nicola Dall’Asen
Why we love it: Is your skin a little temperamental? Having a few products on hand from Tower 28 may help calm it down. “This brand makes products designed for sensitive skin,” says Nava Greenfield, MD, a board-certified dermatologist at Schweiger Dermatology Group in New York City. Made with just three ingredients—water, sodium chloride, and hypochlorous acid—the SOS Daily Rescue Facial Spray “Can help with skin irritation and sensitivities,” Dr. Greenfield notes. Dr. Collins also stands by the product, which is something of a star on TikTok and other social media platforms. “This is a cult-favorite in the clean beauty world and for good reason,” Collins says. “It’s clinically tested for eczema, affordable, and great for calming flare-ups. It’s especially helpful for reactive or compromised skin.”
Nicola Dall’Asen before applying Tower 28 SOS Daily Rescue Facial Spray
Nicola Dall’Asen
Nicola Dall’Asen after applying Tower 28 SOS Daily Rescue Facial Spray
Nicola Dall’Asen
Tester feedback from senior news editor Nicola Dall’Asen
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“I wouldn’t normally reach for an acid-based face mist over a hydrating one, but when you’re in physical therapy three times a week, having a pore-clearing treatment on the go becomes a necessity. The SOS Facial Spray gives me the best of both worlds thanks to its hypochlorous acid, which isn’t just antibacterial but also anti-inflammatory.” —Nicola Dall’Asen, senior news editor
More to know
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- All ingredients: water, sodium chloride, hypochlorous acid
- Sizes: 1 fl oz., 4 fl oz.
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